Francesca Lavatelli Selected Research

Immunoglobulin Light Chains (Immunoglobulin Light Chain)

1/2022	Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation.
1/2022	An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis.
8/2021	Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics.
1/2020	Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.
1/2019	The concurrency of several biophysical traits links immunoglobulin light chains with toxicity in AL amyloidosis.
1/2019	Zebrafish model of amyloid light chain cardiotoxicity: regeneration versus degeneration.
1/2019	Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient.
12/2017	Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
11/2017	Proteotoxicity in cardiac amyloidosis: amyloidogenic light chains affect the levels of intracellular proteins in human heart cells.
6/2016	The impact of renal function on the clinical performance of FLC measurement in AL amyloidosis.

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Francesca Lavatelli Research Topics

Disease

32	Immunoglobulin Light-chain Amyloidosis 01/2022 - 04/2005
31	Amyloidosis 03/2022 - 05/2006
10	Amyloid Plaque 01/2021 - 01/2007
5	Cardiomyopathies (Cardiomyopathy) 01/2019 - 09/2013
3	Transthyretin-Related Hereditary Amyloidosis 01/2021 - 06/2012
3	Cardiotoxicity 01/2020 - 11/2016
2	Heart Failure 01/2019 - 04/2009
2	Multiple Myeloma 06/2014 - 04/2005
2	Heart Diseases (Heart Disease) 04/2014 - 12/2011
1	Optic Atrophy 11/2015
1	Malnutrition (Nutritional Deficiencies) 10/2015
1	Body Weight (Weight, Body) 10/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 09/2013
1	Renal Insufficiency (Renal Failure) 05/2012
1	Weight Loss (Weight Reduction) 03/2012
1	Waldenstrom Macroglobulinemia (Macroglobulinemia) 02/2011
1	Rheumatic Diseases (Rheumatism) 10/2009
1	Proteinuria 03/2009

Drug/Important Bio-Agent (IBA)

26	Amyloid (Amyloid Fibrils)IBA 03/2022 - 01/2007
20	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2022 - 02/2006
20	Proteins (Proteins, Gene)FDA Link 08/2021 - 01/2007
7	Dexamethasone (Maxidex)FDA LinkGeneric 04/2014 - 04/2005
5	Prealbumin (Transthyretin)IBA 01/2021 - 08/2008
4	Melphalan (Alkeran)FDA LinkGeneric 04/2014 - 07/2007
3	Amyloidogenic ProteinsIBA 01/2020 - 08/2008
3	Bortezomib (Velcade)FDA Link 01/2017 - 02/2011
3	Biomarkers (Surrogate Marker)IBA 11/2014 - 12/2011
3	pro-brain natriuretic peptide (1-76)IBA 05/2012 - 05/2006
3	Thalidomide (Thalomid)FDA Link 01/2012 - 04/2005
3	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2011 - 05/2006
2	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 11/2015
2	Congo RedIBA 01/2018 - 02/2012
2	Lenalidomide (CC 5013)FDA Link 03/2013 - 01/2012
2	ProteomeIBA 06/2012 - 08/2008
2	Immunoglobulin M (IgM)IBA 02/2011 - 03/2009
1	Epidermal Growth Factor (EGF)IBA 01/2021
1	fibulinIBA 01/2021
1	Atrial Natriuretic Factor (ANF)IBA 01/2021
1	Islet Amyloid PolypeptideIBA 01/2021
1	Extracellular Matrix ProteinsIBA 01/2021
1	SynucleinsIBA 01/2021
1	LatexIBA 10/2017
1	AlbuminsIBA 01/2017
1	CreatinineIBA 01/2017
1	GlycosaminoglycansIBA 01/2016
1	CollagenIBA 01/2016
1	LipidsIBA 01/2016
1	Protein AggregatesIBA 01/2016
1	Acyl-CoA OxidaseIBA 11/2015
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 11/2015
1	CalciumIBA 09/2013
1	Alkylating AgentsIBA 03/2013
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/2013
1	Natriuretic PeptidesIBA 05/2012
1	proadrenomedullinIBA 12/2011
1	AdrenomedullinIBA 12/2011
1	TroponinIBA 12/2011
1	trans-crotonin (CTN)IBA 12/2011
1	Rituximab (Mabthera)FDA Link 02/2011
1	AA amyloidosisIBA 10/2009
1	Staphylococcal Protein A (Protein A)IBA 03/2009
1	Sepharose (Agarose)IBA 03/2009
1	Troponin IIBA 03/2009
1	ApolipoproteinsIBA 08/2008
1	Peptides (Polypeptides)IBA 08/2008
1	Protein Isoforms (Isoforms)IBA 08/2008
1	polyacrylamideIBA 08/2008

Therapy/Procedure

9	Therapeutics 01/2020 - 04/2005
2	Stem Cell Transplantation 04/2014 - 04/2009
1	Aftercare (After-Treatment) 01/2020
1	Salvage Therapy 01/2012
1	Lasers (Laser) 08/2008